Cancer Networks

We construct an EMT transcriptional regulatory circuit by combining existing Epcam− and Epcam+ networks in squamous cell carcinoma (SCC) and the other literature data. The activating links are shown as blue lines and arrows, and the inhibitory links are shown as red lines and dots.

Reference:

V. Kohar and M. Lu. (2018) Role of noise and parametric variation in the dynamics of gene regulatory circuits. NPJ Syst. boil. Appl. 4: 40 PDF

A comprehensive regulatory network of glycolysis and OXPHOS. The network is composed of the master regulators AMPK and HIF-1 (red ovals), downstream target genes of the master regulators and oncogenes (green ovals), the enzyme genes (orange ovals), and metabolites (yellow rectangles). Black arrows represent excitatory regulation and black bar-headed arrows represent inhibitory regulation. Purple solid lines represent the chemical reactions in metabolic pathways and purple dotted lines represent the transportation of metabolites.

Reference:

D. Jia, M. Lu, K.H. Jung, J.H. Park, L. Yu, J. Onuchic, B.A. Kaipparettu, H. Levine. (2019) Elucidating Cancer Metabolic Plasticity by Coupling Gene Regulation with Metabolic Pathways, Proc. Natl. Acad. Sci. U.S.A. 116(9): 3909-18 PDF